Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Background: Idiopathic premature ventricular complexes (PVCs) are considered a benign form of cardiac arrhythmia. However, several reports demonstrated that frequent PVCs were associated with left ventricular (LV) dysfunction, increased LV dimensions and cardiomyopathy. Case Report: A 52-year-old lady with underlying diabetes mellitus, hypertension and dyslipidemia presented with dyspnea and palpitation. Echocardiography showed ejection fraction (EF) of 25% with LV systolic diameter 5.2cm and mild functional mitral regurgitation (MR). Holter revealed 13657 isolated and couplet PVCs which represented 11.2% of total QRS count in 24 hours. Cardiac MRI showed no inducible ischemia, fibrosis, infarction or inflammation. Her baseline 12-lead ECG showed inferior axis PVCs with left bundle branch block morphology. Electrophysiology study using the Carto® 3 System (Biosense Webster, Irv

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Introduction The wearable cardioverter defibrillator (WCD) has recently been introduced as a therapy to reduce mortality in patients presumed to be increased risk for sudden arrhythmic death. Its efficacy appears to be implied by its proven ability to detect and defibrillate VT/VF. However the currently available data on the WCD is non-randomized and comes from several reports of single center experiences, and reviews of post market release, often vendor supported, registry data. In the absence of randomized trials, the effect of the WCD on patient survival cannot be determined. The mere ability to shock terminate VT/VF by the WCD does not suffice to assume survival benefit when used in large patient populations. These severe limitations have been acknowledged in the recent AHA science advisory report [ 1 ], providing a "tentative interim framework" resulting in mostly class II b

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Hypertension is one the major preventable causes of death and morbidity. The prevalence of hypertension is approximately 30-35% at studies conducted in countries. Today; the role played by hypertension in the development of heart failure and coronary heart disease and the benefits of primary prevention with effective treatment have been clearly demonstrated. The significance of treatment of hypertension in terms of secondary prevention has also been established in patients with heart failure and coronary heart disease. By the current guidelines, hypertension treatment goals has been individualized and specific patient groups have also been amide to provide the highest benefit from therapy. Early identification and effective treatment of hypertension therefore has vital importance for both primary and secondary prevention. Keywords: Hypertension; Coronary artery disease; Heart f

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract There is an old saying that health is wealth. Every organ of a human being is important. But heart is the most sensitive organ. Increased blood pressure and blockage of arteries are the two important symptoms of the heart problem. The present article is intended for the benefit of the common man to guide him to maintain a healthy heart, reducing his chances to fall ill and to seek medical remedies. Keywords: Guidance for healthy heart Opinion This article is concerned mainly with the problems of the healthy functioning of the most important and the sensitive organ, the heart of a human being. At the outset, I wish to assert that I am not a cardiologist, nor a doctor with a medical degree. However, I am a qualified scientist of long standing with knowledge and experience of several fields of the modern man. It is believed that

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract The use of prostaglandin E1 in peripheral occlusive arterial disease is an option for patients for who interventional options are not present. This study assessed the patient reported outcomes and perception of benefits of infusion therapy. 30 patients who completed their 5th month of infusional therapy were included in the study. 3 patients had major lower extremity amputations, 13 had minor lower extremity amputations during the course of infusion therapy. The mean visual analogue scale score prior to treatment was 8.5 prior to treatment and the VAS score was 6.2 post infusion. All patients were satisfied to continue their treatment with PGE1 and perceived a benefit from the therapy. Thus infusional PGE1 is a therapeutic option for patients in whom revasularisation options are not available. Keywords: Prostaglandin E1; Peripheral vascular disease; Outcome

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY   Abstract Coumarins (2H-1-benzopyran-2-one), an important class of heterocyclic compounds, and its derivatives can be found in many natural or synthetic drug molecules and possess versatile bioactivities making them important molecules for medical practitioners and medicinal chemists. Coumarins have found applications in drug molecules especially related to oncogenic and cardiovascular dysfunctions. Cardiovascular diseases and cancer are lifestyle diseases that have become plague to the society. This review highlights the bioactivities of Coumarins towards these life threatening diseases. Keywords: Coumarins; Anti-cancer; Cardio-vascular; Anti-coagulant; Anti-oxidant Introduction Coumarins (1), are naturally occurring fragrant compounds belonging to the benzopyrone family and have been used in perfumes since 1882 [ 1 ]. Coumarins have also attracted the inter

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract The information provided by diagnostic imaging technologies is an invaluable tool for managing cardiology patients. However, one must be careful not to make clinical decisions based exclusively on an image produced by diagnostic devices because; occasionally this approach could prove misleading. Micro-bubbles in the left heart in a patient undergone mitral valve replacement (MVR) three years back are uncommon and require further evaluation. The differential diagnosis being paradoxical air embolism through a PFO, left atrial rupture, atrial-bronchial or atrial-esophageal fistula and Cavitations/De-gassing. The Cavitation/De-gassing phenomenon is caused by the local pressure drop that occurs during the closure and/or opening of mechanical valve leaflets. Occasionally, these peculiar features of echo cardiographic images generated by cavitations can simulate a mass or vegetation an