Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract The use of prostaglandin E1 in peripheral occlusive arterial disease is an option for patients for who interventional options are not present. This study assessed the patient reported outcomes and perception of benefits of infusion therapy. 30 patients who completed their 5th month of infusional therapy were included in the study. 3 patients had major lower extremity amputations, 13 had minor lower extremity amputations during the course of infusion therapy. The mean visual analogue scale score prior to treatment was 8.5 prior to treatment and the VAS score was 6.2 post infusion. All patients were satisfied to continue their treatment with PGE1 and perceived a benefit from the therapy. Thus infusional PGE1 is a therapeutic option for patients in whom revasularisation options are not available. Keywords: Prostaglandin E1; Peripheral vascular disease; Outcome ...

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Various studies showed the possibility of the Risk Factors to promote a disease in the arterial wall and the following development and progression of the Atherosclerosis with its impact on future vascular events. The early stage of atherogenesis is the atherosclerotic plaque, and the primary-prevention had already proved itself efficacius in this early stage, because its erosion and rupture can lead to thrombus formation on the site of the plaque and vessel occlusion, culminating in Cardiovascular disease (CVD) with a variety of clinical manifestations. The most significant clinical manifestation, in terms of morbility and mortality, is CHD. The aim of the primary-prevention, dietary and lifestyle changes is the regression or slow-down and stability of atherosclerotic plaques, with the control of cardiovascular risk factors. Cardiovascular Risk Various studies showed...