Human Coronary Artery Lesions: 900 MHz Magnetic Resonance Micro Imaging, NMR Spectroscopy, Histopathology and Oxidative Stress Markers-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Aim: 900 MHz Magnetic resonance imaging (MRI) techniques measured the dimensions of atheroma and stenosis in excised human coronary plaque disruption and lipid disorder due to oxidative stress. Hypothesis: Coronary atheroma is a lipid disorder and MRI visible. Materials and Methods: Contiguous cross-sectional T2-weighted fast spin echo MRI images were point-by-point compared with coronary histopathology for quantitation of coronary wall and plaque features. Coronary atheroma tissues were used for NMR spectroscopy and oxidative stress content analysis. Results: 900 MHz MRI images showed distinct measurable wall thickness and vessel radii. The quantitative comparison of lumen areas and wall thickness in endarterectomy specimens using MRI images and histology images showed mean difference 5.0 % for lumen area and 4.5 % for wall thickness. MRI data correlated with the his...