Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY   Abstract Myocardial ischemia/reperfusion injury is a major socioeconomic problem worldwide. Though there are wider advancements, still mortality rate is substantial. This can be overcome by exploring complete pathopysiology of the disease mechanism. High-mobility group box-1 (HMGB1) is recently explored multifunctional protein based on its location. The present short communication gives an idea on multiple biological activities of HMGB1. Introduction Myocardial infarction (MI) is the leading cause of death worldwide. Atherosclerotic plaque formation, blocks the coronary artery and there by leads to MI. Early reperfusion is required to salvage diseased myocardium. Reperfusion in turn damages the myocardium called as reperfusion injury ( Figure 1 ). Myocardial ischemia/reperfusion (I/R) injury aggravates the area of infarction. Though t...

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Quality of life, in almost all the current literature reviewed; affirm that it is a set of conditions and situations that engulf the physical, spiritual, psychological, emotional well being, besides social relationships, family, friends, etc. If we analyze this affirmation, we can say that it is the daily life of every human being, healthy, productive, and active and that has internalized values like dignity and feelings of social belonging. Congestive heart failure is a condition in which the heart is unable to pump blood into the bloodstream in sufficient quantity to meet the needs of the body. (I would like to remind you that I am not a cardiologist and the point of analysis and revision in this article of opinion is about the quality of life and the emotional processes and impacts on the human being). In developed countries 6 to 10% of the population over 65 is affected...