Circulating Soluble-Klotho and IGF-I Responses to Different Exercise Modalities in Young, Elderly and CAD Patients-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Introduction Klotho gene expression in positively influenced by different exercise modalities acting as an epigenetic influencer [1], resulting in increased work capacity, performance, and lifespan, and decreased aging in healthy and diseased populations [2-4]. As is the case with exercise, positive adaptations decrease and diminish with time if exercise training is not maintained. S-Klotho Klotho is a transmembrane protein that provides some control over the sensitivity of the organism to Insulin and appears to be involved in aging [5]. Age-related declines are manifest by a decreased ability for aged skeletal muscle to respond to physiological stimuli such as muscle loading or acute injury, and disease related effects [6-10]. IGF-I IGF-I is critical for normal body growth, development and maintenance, and has important roles in multiple biological systems [11,12]. A variet...