Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Introduction Ischemic heart disease (IHD) is a major cause of mortality and morbidity worldwide. It caused 1 of every 6 deaths in the United States in 2008 [1]. It is also the major contributor to heart failure (HF) which has become a burgeoning disease. According to American Heart Association (AHA) projections, HF prevalence will increase by 46% from 2012 to 2030 [2]. Patients with serious IHD usually, have events such as myocardial infarction (MI) that can result in irreparable loss of viable cardiac mass dramatically affecting their cardiac functions. Despite the important advances achieved in revascularization procedures and medical therapy, many of these patients are left with significant disability [3]. Considering the unclear efficacyof coronary artery bypass grafting (CABG) surgery for these patients and the shortage of donor hearts, a rationale to develop a novel stem cell-bas...