Clopidogrel Induced Thrombotic Thrombocytopenic Purpura-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Clopidogrel is commonly used drug in cardiology practice. Though apparently benign, it can rarely caus! e Thombotic Thrombocytopenic Purpura (TTP). Mechanism of action by which Clopidogrel causes TTP is different than usual. This makes the situation more interesting. Here we are presenting a case of NSTEMI who developed TTP after Clopidogrel. Diagnosis is purely clinical. Early diagnosis and plasmapheresis is lifesaving. A 66-year-old female presents to the hospital for new onset of chest pain. After laboratory and diagnostic workup, NSTEMI was diagnosed. Patient underwent catheterization where triple vessel disease was found, only amenable to CABG. During treatment of NSTEMI, patient received Clopidogrel for 2 days, which was subsequently held in preparation for CABG. After CABG, Clopidogrel was restarted and patient started having dramatic decreases in platelet count and hae...