Mutation in one Molecule Induces Beating Rate Changes by Affecting the Coupled Clock Pacemaker Function-Juniper Publishers
JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Pacemaker function is orchestrated through molecules on the membrane and on the sarcoplasmic reticulum that are coupled by Ca 2 + and post-translation modification signaling. These molecules and signaling cascades form one coupled-clock system. Experimental and computational evidence highlight the coupling between components in this system. However, most studies examine how a given pacemaker mutation causes bradycardia or tachycardia and report changes only for the affected molecule without capturing the overall effect on the coupled-clock system. Here, we provide our opinion on how a mutation in one molecule impacts the beating rate by affecting the coupled clock pacemaker function (and thus not only a single molecule). A better understanding of changes in the coupled-clock system due to a given pacemaker mutation may provide new insights into the changes in physiological pro...