A Systematic Analysis of Literary Case Reports of Protein S Deficiency Implicated in Pathogenesis of Arterial Thrombosis-Juniper Publishers
JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Introduction and background: Protein S is a vitamin K dependent natural anticoagulant. Deficiency of protein S is long known to cause venous thrombosis but not arterial thrombosis. Instances of arterial thrombosis due to protein S deficiency are very rare. So, very little can be known about the phenomenon, which is why this study attempts to elucidate on the patients who have suffered from the disease process. Method: 24 articles describing 27 cases where arterial thrombosis occurred along with protein S deficiency were included and results from the reported cases were collated together then analyzed thoroughly. Results: The minimum age was 4 and the maximum age was 64, where the mean age was 37.07 (±16.88 SD) year, median age being 37 year Cerebral arteries and peripheral arteries are the most commonly involved circulations (each constitute 29.63% of cases), making the coronary...