Dehydrated Human Amnion/Chorion Membrane Allograft Promotes Cardiac Repair Following Myocardial Infarctions-Juniper Publishers
JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract There is a rising need for novel therapies for the treatment of acute myocardial infarction (MI). Dehydrated human amnion/chorion membrane (dHACM) contains a unique array of regenerative cytokines and growth factors, involved in the regulation of tissue healing and modulation of inflammation; therefore, the ability of dHACM to prevent cardiac damage or promote healing in an in vivo mouse model of acute myocardial infarction was investigated. Acute left ventricular MI was induced in mice by coronary artery ligation. dHACM patches were then sutured to the MI zones, or the infarcted hearts were injected with saline as a control. After eight weeks post-treatment, dHACM-treated and saline-treated hearts were histological sectioned and stained with Masson’s trichrome to quantify infarct size or with antibodies for c-Kit for recruitment of c-Kit positive stem/progenitor cells, Ki6...