Percutaneous Left Atrium Appendage Closure as an Option for Systemic Anticoagulation: Success and Safety Outcomes by a Review Series Analysis-Juniper Publishers
JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Objective: To perform a review series about percutaneous LAA closure, evaluating the initial case series and their success and safety outcomes. Methods: A systematic review with standard protocols recommended by PRISMA was performed. We reviewed relevant studies and the absolute numbers of events for each outcome of interest in every study were obtained. RevMan statistical software program was used to synthesize the results. Dichotomous outcomes data were measured and reported as the odds ratio (OR) with their 95% confidence intervals. Heterogeneity across studies was examined with the Cochrane's Q statistic (based on pooled OR) and the I 2 statistic test. Results: Seven studies were included in this analysis, culminating to 1215 patients in the device closure group. The primary outcome studied was ischemic stroke incidence.31 ischemic stroke events occurred in the device