Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Summary Introduction: Calcific aortic valve disease (CAVD) is a disorder of high social significance not only because it is widespread but also because it can progress subclinically over an extended period. After the development of severe aortic stenosis, the 2-year survival rate in the absence of surgical intervention is about 50%. Currently, the causes of this pathological condition and its exacerbation mechanisms remain unknown. Aim: To establish whether polymorphism rs10455872 at the lipoprotein (a) (LP(a)) gene locus, encoding LP(a), increases the risk of aortic valve disease. Material and methods: A total of 146 individuals (38 controls and 108 patients with CAVD) were examined. The blood biochemical parameters on admission were measured using standard techniques. Electrocardiography and transthoracic echocardiography were performed on all the subjects included in the stud...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Aorticstenosis is the most common acquired valvar disease, when severe and symptomatic, surgical approach wasthegold standard therapy. It is Worth noticing that severe aortic stenosis treatment was change in the last years and transcatheter aortic-valve replacement (TAVR) become an important therapy for a specific group of patients with a severe aortic stenosis. The patients schedule for TAVR has been progressively changing from only high risk to intermediary risk patients. After these patients selections a world wide risk models were emerged to stratifie patients before TAVR. The STS score was the most used risk score to refer patients for TAVR. Keywords: Aortic stenosis; Trans catheter aortic-valve replacement; STS score; Valvar disease Introduction Aortic stenosis is the most common acquired valvar disease, when severe and symptomatic, surgical approach w...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Background: Surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) have been shown to improve symptoms and overall survival in patients with severe, symptomatic aortic stenosis (AS). However, there still remains a group of patients not considered as appropriate candidates due to comorbid conditions and/or hemodynamic instability. The purpose of this study is to evaluate the in-hospital mortality of this high risk group undergoing BAV. Methods: An institutional BAV registry was created to compare baseline clinical characteristics with treatment outcomes and its associations with in-hospital mortality. Univariate analyses for continuous variables were performed with analysis of variance and Mann Whitney tests. Univariate analyses for categorical variables were preformed with Pearson chi square and Fischer’s exact test. Multivariate logistic regre...

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Background: Transcatheter aortic valve implantation (TAVI) is already a proven choice of treatment for patients with severe aortic stenosis (AS). There is few data of the real world regarding the echocardiographic and clinical outcome of patients with paradoxical low‐flow low‐gradient aortic stenosis (PLFLG) after TAVI procedure. Objectives: In this study we aimed to compare the echocardiographic and clinical outcome in a group of patients with PLFLGAS after TAVI with a group of high‐gradient aortic stenosis (HGAS), both groups with preserved left ventricle ejection fraction (LVEF). Methods: We studied the baseline echocardiographic parameters and clinical data of 178 patients with severe AS and preserved LVEF before TAVI and after one year of follow up. All data were obtained from the clinical file and the workstation in the echo‐lab of our hospital. Patients with low eje...