Kounis-Zavras Syndrome: from Pathogenesis to Management-Juniper Publishers
JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract The occurrence of acute coronary events in the setting of hypersensitivity reactions following an allergic insult defines the Kounis-Zavras syndrome that was described for the first time by Pfister in 1951 and published as the first description of allergic angina syndrome by Kounis and Zavras in 1991. Since this topic has not been discussed in the international recommendations for cardiology, this review of Kounis-Zavras syndrome aims to provide an update on this rare clinical entity as well as to highlight the particularity and the special features of how to manage this syndrome. Keywords: Kounis-Zavras syndrome; Myocardial ischemia; Allergy; Coronary spasm; Management Introduction Kounis syndrome refers to allergic acute myocardial ischemia in relation with release of inflammatory mediators by activated mast cell leading to coronary artery spasm...