Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Sepsis is one of the leading causes of mortality and morbidity around the world. Myocardial dysfunction is one of the important factors in the hemodynamic compromise seen in sepsis. Numerous mechanisms have been studied in identifying the pathophysiology, however, no definitive hypothesis has been proven. This review attempts to evaluate, and understand some of the known biochemical and pathophysiological mechanisms leading to cardiac dysfunction and sepsis. Introduction Sepsis is the leading cause of mortality and a major healthcare concern worldwide [1]. It is characterized as a life-threatening disease, enhanced by a dysregulated immune host response to a precipitating infection. It’s a multifaceted disease, encompassing various organs and may lead to end-organ failure, shock and death. In a healthy human being the pro-inflammatory response triggered by microbes is cou...