Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract The radial artery is now the preferred access route for most cardiologists performing coronary angiography and percutaneous coronary intervention in Europe. However, its use across the rest of the world remains variable. Transradial access provides a number of advantages over the femoral route, including reduced risk of bleeding, but is often technically more challenging, particularly early in the learning curve. Abbreviations: Alternative medicine; Life style diseases; Diabetes mellitusACS: Acute Coronary Syndrome; STEMI: ST-Elevation Myocardial Infarction; GTN: Glycerltrinitrate; RAO: Radial Artery Occlusion; PROPHET: Prevention of Radial artery Occlusion-Patent Hemostasis Evaluation Trial; RIFLE-STEACS: Radial Versus Femoral Randomized Investigation in ST-Elevation Acute Coronary Syndrome Bakground The first published use of transradial coronary angiography was by C

JUNIPER PUBLISHERS-OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Purpose: The variable response to clopidogrel is multi-factorial; cigarette smoking is thought to be one of these factors as smoking is a known inducer of CYP1A2, one of the predominant isoenzymes responsible for activation of clopidogrel. The Purpose of this study is to finds out the impact of cigarette smoking on clopidogrel-induced platelet inhibition. Methodology: retrospective analysis of a prospective cohort of 90 Saudi patients with acute coronary syndrome who underwent coronary angioplasty with drug eluting stents. Pre-procedure arterial blood sample was taken from every patient for assessment of platelet function (Verify Now P2Y12 point-of-care assay. Results: Of these ninety patients, 26 (28.8%) patients were smokers. Patients received clopidogre l300 mg or 600mg as loading and 75mg per day as maintenance dose. The Inhibition of platelet aggregation percent (IPA