Juniper Publishers Journal of Cardiology and Cardiovascular Therapy

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Historically biodegradable materials for implants which serve as a temporary function have been used in therapeutic medicine in areas that includes wound closure, interventional technologies, drug delivery, oncology and cardiovascular surgery and were designed to overcome the disadvantages of permanent metallic based devices. Various types of materials are used for the development of scaffold strut like polymers (poly-L-Lactic acid, tyrosine poly carbonate) and alloys (Mg, platinum). BVS (bioresorbable vascular scaffold) are mainly useful for the restoration of functional endothelial coverage, allows the restoration of physiological vasomotion, allow to graft stented segments of coronary artery, enables prevention of acute recoil or occlusion, provide inhibition of in segment restenosis through efficient drug elusion and no foreign material left behind. Along with the advantages th...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY   Abstract Objectives: To detect early diastolic dysfunction in the left ventricle in hypertensive patients with preserved ejection fraction using 2D speckle tracking echocardiography. Methods: This is a prospective study that was carried on (80) hypertensive patients referred to Al Azhar university hospital outpatient clinic for evaluation and treatment of hypertension and (20) age and sex matched healthy volunteers as a control group. All subjects underwent convential echocardiographic examination and assesment of diastolic dysfunction by speckle tracking. Conclusion: Impairment of diastolic function detected by speckle tracking in hypertensive patients (with and without LVH). Keywords: Hypertension; Speckle tracking; Echocardiography Introduction Hypertension is a well-recognized risk factor for cardiovascular disease and a major contributor t...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Introduction and background: Protein S is a vitamin K dependent natural anticoagulant. Deficiency of protein S is long known to cause venous thrombosis but not arterial thrombosis. Instances of arterial thrombosis due to protein S deficiency are very rare. So, very little can be known about the phenomenon, which is why this study attempts to elucidate on the patients who have suffered from the disease process. Method: 24 articles describing 27 cases where arterial thrombosis occurred along with protein S deficiency were included and results from the reported cases were collated together then analyzed thoroughly. Results: The minimum age was 4 and the maximum age was 64, where the mean age was 37.07 (±16.88 SD) year, median age being 37 year Cerebral arteries and peripheral arteries are the most commonly involved circulations (each constitute 29.63% of cases), making the coronary...

JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Background and purpose: All anti-thrombotic drugs presently available cause increased bleeding, a most undesirable effect. Our aim was to test a novel anti-thrombotic drug [Th001] which, theoretically should not suffer from this disadvantage. Experimental approach: The trial design was a double-blind, placebo controlled, paired crossover, with 99% power for showing a difference in skin bleeding time. n=48 Caucasian patients, age 69.0±6.6 years, 38 male, 10 female, with stable atherothrombotic disease and other stable chronic diseases, treated with aspirin and statin. There was no effect on bleeding time (p =0.9729) nor on tests of haemostasis, (Ultegra point of care aggregation test and flow cytometry). The mean platelet count rose from 234.43±67.264 to 246.43±84.14x10-9 per litre, p=0.024. Conclusion: Th001 therapy appears to be a safe method for potential treatment and preventi...