Coenzyme Q10: The Cardiac Bio-energizer in Cardiovascular Diseases-Juniper Publishers


This systematic review is aimed to identify, evaluate and summarize the role of oral Coenzyme Q10 supplementation in prevention and treatment of cardiovascular diseases (CVD). CoQ10 is concentrated primarily in the cellular mitochondria where it functions as a co-factor transferring electrons from Complex I to Complex II, III ultimately resulting in the formation of energy in the form of ATP. Coenzyme Q10 an endogenous antioxidant declines in our body because of various factors like aging, diseases and use of certain drugs like statins, beta-blockers which exacerbate its deficiency. Deficiency of this important endogenous antioxidant CoQ10 results in energy depleted state. Published data and research have suggested that Coenzyme Q10 an endogenous antioxidant has a potential for being used in the prevention and treatment of CVDs, in particular in Heart failure and Ischemic heart disease. Supplementation with CoQ10 not only corrects the deficiency of CoQ10 by improving the circulating levels of CoQ10 but also shows a significant improvement in various parameters like ejection fraction, NYHA class, symptom score and survival rate. Being a natural substance with low toxicity and good efficacy it would be appropriate to recommend CoQ10 as an adjunct to conventional therapy in selected group of patients.

https://juniperpublishers.com/jocct/JOCCT.MS.ID.555560.php

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