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Hypertensive Cardiomyopathy: Diagnostic Approach and Clinical Differentiation from Hypertrophic Cardiomyopathy

Abstract Hypertensive Cardiomyopathy (HTN-CM) is a structural cardiac disorder generally accompanied by concentric or eccentric Left Ventricular Hypertrophy (LVH) associated with diastolic or/and systolic dysfunction in patients with persistent systemic hypertension. It occurs in the absence of other cardiac diseases capable of causing myocardial hypertrophy or cardiac dysfunction. Long standing arterial hypertension (HTN) leads to structural and functional myocardial abnormalities resulting in myocardial ischemia, fibrosis, and hypertrophy. HTN-CM is predominantly a disease of impaired relaxation rather than impaired contractility, although subtle myocardial systolic abnormalities could be detected recently by Global Longitudinal Systolic Strain (GLS) Speckle Tracking Echocardiography (STE). Importantly, the accompanying LVH is itself a risk factor for mortality and morbidity and is considered an independent predictor for Sudden Cardiac Death (SCD). Therefore, early d

Heart Failure

Abstract Heart failure (HF) is a complex clinical syndrome that can result from any structural or functional cardiac disorder that impairs the ability of the ventricle to fill with or eject blood. The cardinal manifestations of HF are dyspnea and fatigue, which may limit exercise tolerance, and fluid retention, which may lead to pulmonary congestion and peripheral edema [1]. Atrial fibrillation (AF) is the most common arrhythmia in clinical practice, accounting for approximately one third of admissions resulting from cardiac rhythm disturbances [2]. Read More About This Article:  https://juniperpublishers.com/jocct/JOCCT.MS.ID.555558.php Read More   Juniper Publishers Google Scholar   Articles:   https://scholar.google.com/citations?view_op=view_citation&hl=en&user=7G73aakAAAAJ&citation_for_view=7G73aakAAAAJ:_FxGoFyzp5QC

Wishing you and your family Happy Easter

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JUNIPER PUBLISHERS Happy Easter

Chronic Hypoxemic Syndrome and Congenital Heart Disease in Adults: A Multisystemic Disorder-Juniper Publishers

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JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Congenital heart disease is the most frequent malformation, many cases are complex cyanotic congenital heart defects characterized by low arterial oxygen saturation. Unrepaired intracardiac or extracardiac congenital heart defects which causes a persistent right to left shunt, they are responsible for hypoxemic syndrome, this is a multisystemic disorder affecting various organs and symstems: hematopoietic, central nervous, gastrointestinal, urinary, cardiovascular, Immune, musculoskeletal and endocrine. The objective this review is to explain the pathophysiological mechanisms adapted to the chronic hypoxia, the consequences derived from the affectation in the different systems. The diagnostic approach and management in centers specialized in adults with congenital heart disease. This review was made with articles search sources in databases PubMed, ScienceDirect, OVID, HINARI, S

Young at Heart: Recent Advances in the Genetics of Congenital Heart Disease and Translational Care-Juniper Publishers

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JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract Congenital Heart disease affects almost 1% of babies born in the UK, but few receive a genetic diagnosis. Identifying a genetic cause is important for that individual’s healthcare, and that of their family. It enables accurate genetic counselling, including discussion of reproductive choices. Significant advances have been made in identifying genes that are involved in the developing heart and congenital heart disease, and research has moved away from single family studies towards genetic sequencing of large cohorts. This will bring new challenges for clinicians and researchers related to data sharing and incidental findings. In the future, we hope that new treatments can be developed based on our understanding of the complex genetic networks underlying development of the heart. Keywords: Congenital heart disease; Genetics; Inheritance; Chromatin; Sequencing; Syndromic; Non-syn

Post Myocardial Infarction Ventricular Septal Defect-Juniper Publishers

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JUNIPER PUBLISHERS - OPEN ACCESS JOURNAL OF CARDIOLOGY & CARDIOVASCULAR THERAPY Abstract ST segment elevation myocardial infarction (STEMI) is a well described medical emergency with significant strides in medical management drastically improving survival, however its complications are less frequently described. It can be a difficult task to determine the cause of an acute decompensation after successful revascularization of a STEMI. The differential includes a myriad of acute medical and surgical emergencies, including re-occlusion, stent thrombosis, and mechanical dysfunction of the free wall, septum or valves. Among these is the rare and often fatal acquired ventricular septal defect (VSD). A high index of suspicion of this complication is necessary for early recognition to improve survival. We present a case of an 83-year-old male who after 14 days of a hospital admission for STEMI with successful revascularization had an acute decompensation from hypoxemia refra